![]() A decrease in excitability and insulin sensitivity causes the amount of GLUT4 translocated to the cell surface to decrease so that the concentration of glucose taken from the blood is also reduced as a result, blood glucose levels will remain high. An increase in blood viscosity will cause a decrease in blood flow rate, which can cause a decrease in the amount of insulin that can bind to its receptors in the tissue and is associated with insulin resistance. Increased blood glucose levels can lead to increased blood viscosity. Hyperglycemia conditions can result in increased levels of reactive oxygen species and reactive nitrogen species, which are highly reactive molecules that can cause cellular damage and oxidative stress. This condition is a primary characteristic of DM. Hyperglycemia occurs when glucose levels in the blood increase. As such, an increase in temperature in the red and infrared spectrum can be used for additional treatment in medicine with a relatively fast healing time. Hyperthermic conditions will increase the concentration of free Calcium (Ca 2+) in the cytosol, which can eventually induce translocation of glucose transporter 4 (GLUT4) in striated muscle cells this will increase glucose uptake from the blood, thereby increasing the blood flow rate through vasodilation effects. Accordingly, when the body is exposed to infrared rays, it will absorb photons/infrared energy, resulting in electrons being excited, before transitioning to a ground state by emitting biophotons, which generate heat and will increase body temperature or give rise to hyperthermia. It is known that the body contains electrolyte fluid, a solution of ions (positively and negatively electrically charged) with the same vibrational frequency as infrared. ![]() Erythrocyte aggregate conformation regulation is possible due to the presence of hemoglobin containing ferrous ions, which imbues red blood cells/erythrocytes with paramagnetic properties and enables them to be influenced by external magnetic fields (permanent or electromagnetic). A magnetic field can control the conformational arrangement of aggregated erythrocytes, making it easier to follow the dynamics of blood flow in the vessels. Similar to electric fields, magnetic fields can also lower blood viscosity. The dilation of blood vessels can increase the blood flow rate, which, in turn, will lead to a decrease in blood viscosity. An electric field can induce changes in transmembrane potential and have a dilating effect on blood vessels by stimulating the release of endothelial-derived nitric oxide, which can give rise to the relaxation of smooth muscle in blood vessel walls. Electric fields can have positive physical, cellular, and physiological effects on animals included in experiments. Based on the results of these studies, the current paper hypothesizes that the combination of electric fields, magnetic fields, and infrared rays can reduce the diameter of the Langerhans islets of diabetic mice ( Mus musculus). ![]() One such alternative involves combining a magnetic field, electric field, and infrared light. Accordingly, alternatives for treating diabetes mellitus (DM) are needed. However, these methods can cause hypoglycemia, weight gain, and digestive tract disorders. Diabetes is typically treated with oral antidiabetic medicines, such as sulfonylureas and thiazolidine, as well as insulin injection. ![]()
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